Project Nephros
Developing sustainable, reusable hemofiltration membranes for improved dialysis and future implants.
Team members:
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Sean Griffiths
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Bora Ith
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Fiona Thai
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Benjamin Kang
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Carolyn Chhor
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Chloe Wang
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Jessica Levitz
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Mahil Thomas
Advisor:
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Julie Dao
Project History
Project Nephros began with an extensive literature review, gathering critical research on nephrology and current dialysis treatments. Early efforts focused on understanding albumin loss and the removal of middle to high molecular weight uremic toxins, such as beta 2 microglobulin, fibroblast growth factor 23, and tumor necrosis factor alpha. These foundational studies paved the way for developing a sustainable, reusable hemofiltration membrane. The initial research not only defined the scientific challenges but also highlighted the potential for these membranes to serve as stepping stones toward implantable artificial kidneys—an ultimate, long-term goal in nephrology treatment.
Goals
The primary goal is to create a sustainable, reusable hemofiltration membrane that minimizes water usage and waste while efficiently filtering key uremic toxins. The project emphasizes maintaining albumin balance and improving toxin removal, laying the groundwork for eventual implantable artificial kidney solutions.
Plans
In 2025, the team plans to expand significantly, organize field trips with advisors, and complete the literature review. Efforts will focus on developing a cost-effective manufacturing theory, with the aim of producing a functional membrane prototype by the end of the year, moving closer to the long-term implantable artificial kidney challenge.